Cellular immune phenotypes of depression: a gateway to precision medicine 

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In her debut blog, Fabiana Corsi-Zuelli summarises a recent systematic review and meta-analysis investigating the role of peripheral immune cells in depression, with a focus on implications for future immunotherapy trials.

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Pulpotomy in permanent teeth with bioactive materials

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This review evaluating the evaluate the success rate of pulpotomies on permanent teeth using ProRoot MTA, compared to calcium hydroxide or other bioceramic cements included 16 RCTs. The findings suggest better outcomes with MTA than calcium hydroxide. However 10 of the studies were at high risk of bias and the overall certainty of evidence was assessed as low.

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The international prevalence of suicidal ideation and behaviour in youth

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Lucy Barrass summarises a systematic review published in the Journal of the American Academy of Child & Adolescent Psychiatry that explores the international prevalence of suicidal ideation and behaviour among young people across global regions.

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Online psychodrama for dementia: “Zooming” our way towards improvement?

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KCL Masters student Azza Elsheikh summarises a recent qualitative study exploring the experiences of online psychodrama for people with dementia.

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Helmet use and maxillofacial injuries due to bicycle and scooter accidents

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This review of the effect of helmet use on the incidence of maxillofacial injuries due to cycling, e-bike, scooter, and e- scooter accidents included 14 studies. The findings suggest a significant reduction in the risk of maxillofacial injury with helmet use Odds ratio = 0.682 (95%CI; 0.565 to 0.822). Although all but 2 of the studies were retrospective and only 5 studies were considered to be of high quality .

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Virtual reality therapy for psychosis: positive patient experiences and few side effects

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Steven Parkes considers a randomised controlled trial exploring the satisfaction and side effects of gameChange, a virtual reality intervention targeting anxiety in every day situations for patients with psychosis.

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Non‐surgical procedures to accelerate orthodontic tooth movement

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This Cochrane review update was to assess the effect of non‐surgical adjunctive interventions on the rate of orthodontic tooth movement and the overall duration of treatment included 23 RCTs.The findings suggest there may be limited benefit from photobiomodulation application for accelerating discrete treatment phases but this should be interpreted very cautiously as the findings may not be clinically important and the evidence is of low to very low certainty.

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Interventions to foster resilience in nursing staff may help (a little) in the short-term

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Olga Lainidi summarises a recent systematic review and meta-analysis investigating the effectiveness of resilience interventions on the mental health of nursing staff.

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Add on iCBT: weak evidence of modest benefits in depression and anxiety

iCBT can be effective in reducing symptoms of depression, anxiety, OCD and PTSD - could its accessibility help reach more people?

Liesbeth Tip and Antigone Lanitis reflect on a recent systematic review and meta-analysis that investigated internet-delivered psychological treatment as an add-on to treatment as usual in depression, anxiety, and PTSD.

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