Salivary biomarkers CYFRA 21-1 and MMP-9 for oral squamous cell carcinoma diagnosis?

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In his first blog for the Dental Elf Rajpal Tattar take a look at a review of the diagnostic accuracy of salivary biomarkers for the detection of oral squamous cell carcinoma (OSCC). The review considers two biomarkers, cytokeratin 19 fragment (CYFRA 21-1) and for matrix metalloproteinase-9 (MMP-9) but there is no conclusive evidence for either at present.

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Parental PTSD in refugees predicts psychiatric contact in offspring

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A group of students from the UCL MSc in Mental Health Studies summarise a cohort study on the risk of childhood psychiatric disorders in children of refugee parents with PTSD.

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One in four UK children exposed to maternal mental illness

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Francesca Bentivegna reviews a national retrospective cohort study which explores the prevalence of maternal mental illness among children and adolescents in the UK during 2005-2017.

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Caries prevention in children: Fluoride varnishes or sealants?

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11 RCTs were included in this Cochrane review which looked at the relative effectiveness of fissure sealants compared with fluoride varnishes for the prevention of caries in the occlusal surfaces of permanent teeth.

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Therapeutic alliance important to help people at risk of suicide

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Charlotte Huggett summarises a naturalistic outpatient study which explores the impact that therapeutic alliance and negative responses from clinicians can have on suicidal ideation in people in therapy.

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Lockdown loneliness: who is lonely before and during the pandemic?

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Aggelos Stamos reviews a recent cohort study led by the team behind the UCL COVID-19 Social Study on the predictors of loneliness before and during the COVID-19 pandemic.

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Metastasis to the oral and maxillofacial region

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This review of metastasis to the oral and maxillofacial region included 217 studies (190 case reports,24 case series ). Metastasis were uncommon, but identified from 29 primary sites, the most common sites being lung the lungs (20.97%), breast (12.06%) and kidney (11.78%).

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Stay fit in response to COVID: simple recommendations and COH-FIT

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Marco Solmi tells us about the importance of physical activity as people in the UK enter a second period of coronavirus lockdown.

He also introduces us to the huge international COH-FIT study, which will help us better understand how the pandemic is affecting people and what can help.

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Powered toothbrushes for patients undergoing fixed orthodontic appliance treatment?

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This review of the effect of powered and manual toothbrushes on oral health during fixed applinace orthodontic treatment included 7 RCTs. The findings suggest no diference between the toothbrush types. However the quality of the evidence is low and the studies are of short duration.

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Social security? Evidence about benefits and mental health

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Andy Bell summarises a collection of recent academic research papers that have sought to understand the impact of a range of changes to the UK benefits system on people’s mental health.

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