Results: 644

For: randomised controlled trial

Reducing stigma and sickness absence: can a low intensity psychological intervention help us ‘Prevail’?

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Emmeline Lagunes-Cordoba summarises a cluster randomised controlled trial exploring the effectiveness of a low-intensity psychological intervention to reduce mental health stigma and improve help-seeking in the workplace.

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Guided self-help for anxiety: the importance of choice

Only 7% of the participants accepted being randomised, while 93% chose their treatment, showing a preference for CAT-GSH; however, CAT-GSH and CBT-GSH were found to result in similar anxiety outcomes at the follow-up assessments.

In her latest blog, Francesca Zecchinato summarises findings from a recent pragmatic, partially randomised, patient preference trial on two forms of guided self-help for anxiety.

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Brief interpersonal therapy may help relieve maternal depression during pregnancy

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In this blog, Francesca Kingston summaries a clinical trial from the US Care Project, which investigated whether depression can be reduced during pregnancy and before birth using a brief, safe intervention.

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High-fluoride toothpaste or high fluoride mouthrinse to prevent white spot lesions in adolescent orthodontic patients – trial

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270 pateints were randomised in this trial to compare high-fluoride toothpaste and high-fluoride mouth rinse for preventing white spot lesions during orthodontic treatment. The findings suggest a benefit for high fluoride toothpaste and fluoride mouth rinse in preventing white spot lesions.

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The Body Project peer-led eating disorders prevention programme shows promise for bulimia nervosa and purging disorder

Across the three trials, 10.6% of Body Project participants went on to develop an eating disorder in comparison to 17.4% of the control groups, indicating promise in the intervention.

Georgie Parker summarises a recent study which outlines the results of three trials exploring the effectiveness of a peer-led dissonance-based programme for preventing the onset of eating disorders.

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Manual v powered toothbrushing in adolescent orthodontic patients – trial

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The aim of this randomised trial was to compare the efficacy of a powered versus manual toothbrush in controlling plaque and gingival health in participants undergoing fixed orthodontic treatment in respect of both the short term and long term. The findings showed no differences between the brush types at any time points ( 1, 6 or 12 months).

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Long-term psychoanalytic psychotherapy for treatment-resistant depression: not cost-effective compared to treatment as usual

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In her debut blog, Ella Tuominen considers the Tavistock Adult Depression Study (TADS), which evaluated the cost-effectiveness of long-term psychoanalytic psychotherapy for treatment resistant depression compared to treatment as usual.

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New US research suggests that primary care practices can help people who drink too much alcohol, so why aren’t we doing it?

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Sally Adams on new research from the US (a cluster randomised implementation trial) that integrates alcohol-related prevention and treatment into primary care.

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Step-by-Step: promising digital app for Syrian refugees with depression

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Dafni Katsampa critiques a recent randomised controlled trial evaluating the effectiveness of Step-by-Step, a WHO-guided digital intervention for Syrian refugees with depression in Lebanon.

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Psilocybin for ‘treatment-resistant depression’: an island of hope in an ocean of uncertainty?

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In this blog, UCL MSc students consider an RCT published in the New England Journal of Medicine, which suggests that psilocybin-assisted psychotherapy may help reduce depression in people with severe and enduring illness, but side effects are common and more research is needed to look into longer term effects.

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