There has been a lot of discussion over recent years about the ways in which genetic testing may help make the treatment of depression become more targeted and effective. The theory is that genetic markers may help predict how different people are likely to respond to different drugs. This is clearly something that would interest [read the full story…]
Benzodiazepines are an effective treatment for acute anxiety and transient insomnia, but guidelines advise that they should not be prescribed for longer than a few weeks as their long-term use can lead to dependency and falls in older people (amongst other things). The evidence appears compelling and yet benzodiazepines are still widely prescribed in the [read the full story…]
The relationship between attention-deficit hyperactivity disorder (ADHD) and substance use in children is hotly debated. ADHD symptoms include inattention, hyperactivity/impulsivity and conduct disorders, and there’s considerable interest in finding out which of these predicts early substance use. If we have reliable evidence that answers this question we can make informed decisions about treating ADHD and [read the full story…]
Some of the older elves in the woodland don’t join in with our social activities as much as they used to. The younger elves call them ‘cranky’ and laugh at them sitting alone in their tree houses. Personally I worry that they might be feeling lonely and I doubt that shutting themselves away from the [read the full story…]
Published yesterday in the Lancet, the Multicentre Study of Self-harm in England is a large (30,950 patients) cohort study of people presenting to hospital emergency departments in Oxford, Manchester and Derby, with self-poisoning or self-injury during 2000-2007. We know that people who self-harm have an increased risk of dying early, but this study tries to [read the full story…]
It’s hard not to picture scenes from the great war films when we consider the mental health of veterans. Images from Apocolypse Now, The Deer Hunter, Full Metal Jacket and The Hurt Locker are etched onto the public psyche in such a way that it’s sometimes hard to separate fact from fiction. Research has shown [read the full story…]
This well conducted prospective cohort study looks at the impact that cannabis use can have on the development of the brain over a 20 year period, from the teenage years to middle-age. The research studied 1,037 people from New Zealand who are part of the Dunedin Multidisciplinary Health and Development study, which followed participants from [read the full story…]
Bisphosphonates (BPs) are used for the treatment of a range of bone problems, e.g., osteoporosis, or bone metastases of malignant cancer. In 2003 the condition of bisphosphonate related osteonecrosis of the jaw (BONJ) was reported. The aim of this retrospective cohort study was to estimate the cumulative incidence and risk ratio for ONJ (osteonecrosis of [read the full story…]
Polypharmacy is the simultaneous use of two or more drugs to treat a single health condition. Polypharmacy is often used in the treatment of schizophrenia where people are regularly prescribed two or more antipsychotics, as well as antidepressants and/or benzodiazepines, although there is little evidence to prove that these combinations are more effective than monotherapy. [read the full story…]
There is an increasing body of evidence showing that depression and anxiety are linked with other health conditions like cancer and cardiovascular disease. I’ve blogged about the link between depression and stroke, and there are a number of other studies that show an association between psychological distress (the symptoms of depression and anxiety) and mortality, [read the full story…]
