Helge Hasselman summarises a Cochrane review of tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents, which finds low quality evidence and no justification for prescribing these drugs in this group of patients.
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Andrew Shepherd reviews the recent controversial BMJ study that suggests the FDA black box warning about antidepressant use in young people, may have inadvertently caused an increase in suicidal behaviour. He finds it’s not quite that clear cut.
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Major depressive disorder (MDD) is unfortunately a relatively common condition in children and adolescents. Depression is estimated to affect 2% of pre-pubertal children and 5-8% of adolescents (Son et al, 2000). As you might expect, depression has a significant negative impact on the development, functioning and risk for suicide in individuals affected, as well as [read the full story…]
Selective serotonin reuptake inhibitors (SSRIs) have long been suspected to – paradoxically- increase suicidal behaviour in adolescent and pediatric patients. Consequently, national watchdogs started issuing black label warnings for all SSRIs to educate physicians and patients about associated risks. While clearly curbing the amount of antidepressant prescriptions, concerns have been voiced that this step has [read the full story…]
The NICE guideline for depression in children and young people was published way back in September 2005. Any elf worth his salt will tell you that a whole heap of evidence has been published since then, so it’s good to see an evidence update appear this week from NICE, which brings together research published from 17th [read the full story…]
I wonder if the timing of this publication was planned to be so close to the release of DSM-5, but this debut guidance on social phobia (now known as social anxiety disorder) is certainly going to ruffle some feathers. It fuels the discussion about the medicalisation of human personality traits and some will see it [read the full story…]
Much of the research about depression in children and adolescents focuses on how to treat the illness during the acute phase. This review from the Cochrane Depression, Anxiety and Neurosis Review Group is more concerned with the ways in which interventions can be used to prevent relapse or recurrence of depressive disorders. The review looks specifically at two [read the full story…]
Young people with autism spectrum disorders (ASD) are usually given some kind of behavioural or educational intervention to help improve their overall functioning. However, in some cases, those individuals who have high levels of repetitive, obsessive-compulsive type behaviours and mood disorders are treated with drug interventions, although there is little high quality evidence to support [read the full story…]
In 2004 the US Food and Drug Administration published a “black box” warning that highlighted an increased risk of suicide and suicidal thoughts in young people who were taking antidepressants. This warning was updated in 2007. A new analysis of 41 randomised controlled trials has been published in the Archives of General Psychiatry, which suggests [read the full story…]
Obsessive compulsive disorder (OCD) is a condition that is usually associated with obsessive thoughts and compulsive behaviour. It’s one of the most common mental health problems in young people, with an estimated 5% of children and teenagers suffering from the chronic condition. Studies have shown that SSRI antidepressants and cognitive behavioural therapy (CBT) are both [read the full story…]
