comorbidity

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Introduction

Comorbidity, or the co-occurrence of two distinct medical conditions, is a common phrase in both physical and mental health. Whilst the term was originally conceived to describe medical phenomena, the term was adopted by psychiatry in the description of more than one clinical presentation occurring simultaneously. However, its use in psychiatry is not without controversy. 

What we know already

Large-scale prevalence data can seemingly tell us much about the high rate of comorbidity in mental health. Data from US National Comorbidity Survey, for example, suggested that, of those reporting mental health difficulties (across a 12-month prevalence), only 55% carried a single psychiatric diagnosis.

One important area of recent research concerns the rates of comorbidity of physical and mental health difficulties, particularly in the area of chronic health conditions. Mental Elf blogs have reported that people with schizophrenia are significantly more likely to die from heart disease and cancer; while the National Schizophrenia Audit calls for improved monitoring of physical health in people with schizophrenia. We know that depression and anxiety are more common when a person has a chronic health problem, and this comorbidity leads to poorer clinical and quality of life outcomes. This has led to an increase in interventions targeting the psychological consequences of chronic ill health.

Areas of uncertainty

The controversy in psychiatric comorbidity is the issues of mutual exclusivity. We are not able to conclude as to whether ‘comorbid’ psychiatric diagnoses are separate clinical entities, or multiple features of the same underlying cause. This has led to much criticism of the term ‘psychiatric comorbidity’.

Furthermore, certain diagnostic labels, such as personality disorders, attract particular scrutiny, due to their high levels of comorbidity with other mental health diagnoses. Similarly, people often meet the criteria for more than one personality disorder. This again creates uncertainty as to the precise nature of the condition, or conditions, being diagnosed.

What’s in the pipeline?

The recent publication of the Diagnostic and Statistic Manual (DSM)-5 seemingly retains the notion that multiple distinct clinical diagnoses exist, thus maintaining the argument for psychiatric comorbidity. Alternative conceptualisations have been suggested, along dimensional models, such as ‘anxious-misery’, ‘externalising’ and ‘fear-based’ dimensions. However, these were not adopted in the DSM-5.

As our understanding of mental health conditions continues to improve, so too hopefully will our understanding of comorbidity, and its relevance to psychological and psychiatric phenomena.

References

First, M. B. (2005). Mutually exclusive versus co-occurring diagnostic categories: the challenge of diagnostic comorbidity. Psychopathology, 38, 206-210. [Abstract]

Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry, 62, 617-627. [Abstract]

Naylor, C., Parsonage, M., McDaid, D., Knapp, M., Fossey, M. and Galea, A. (2012) Long-term conditions and mental health: the cost of co-morbidities. The King’s Fund, London, UK. [Full text]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our comorbidity Blogs

Prevalence of comorbid personality disorder and alcohol use disorder

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People diagnosed with “personality disorders” are likely to also experience alcohol problems.

Dean Connolly summarises a recent systematic review that confirms the very high prevalence of comorbid personality disorders and alcohol use disorders.

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Autism and psychiatrists: experience, knowledge and attitudes revealed in new survey

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Eloise Stark looks at a recent online survey which seeks to understand psychiatrists’ knowledge, attitudes and experiences in identifying and supporting their patients on the autism spectrum.

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We know how to reduce premature deaths from co-morbid mental health and substance use problems, so why aren’t we doing anything about it?

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Ian Hamilton looks at a Swedish 42-year follow-up study, which looks at the impact that psychiatric comorbidity can have on premature death in a cohort of patients with substance use disorders.

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How can digital technology help close the mortality gap for people with severe mental illness?

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Lina Gega from the Closing the Gap Network explores a recent review of digital technology for health promotion, which looks at opportunities to address excess mortality in people living with severe mental illness.

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Higher body mass index is associated with a lower subjective wellbeing

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Benjamin Janaway explores a recent mendelian randomisation study that looks at the causal effects between subjective wellbeing and cardiometabolic health.

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Smoking cessation for people with severe mental illness? “Oh yes they can!” SCIMITAR+

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David Shiers and Peter Byrne summarise the new SCIMITAR+ trial out today in The Lancet Psychiatry, which evaluates a bespoke smoking cessation intervention for people with severe mental illness.

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Psychosis and physical health: listening to patients and family carers

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Shuichi Suetani and Sharon Lawn explore a recent viewpoint article on physical health problems in psychosis, which asks: Is it time to consider the views of family carers?

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Physical activity participation in severe mental illness: one step closer? #ClosingTheGapSMI

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Suzan Hassan writes her debut elf blog on a recent research paper that highlights the factors associated with regular physical activity participation among people with severe mental illness.

Today sees the launch of the new Closing The Gap Network in York. Follow #ClosingTheGapSMI on Twitter for live updates throughout the day.

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Transforming mental health throughout the life course #MQScienceMeeting 2019

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André Tomlin sets the scene for the 2019 #MQScienceMeeting which brings together researchers across different disciplines to explore cutting-edge new ways to understand, treat and prevent mental illness.

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Lifestyle training for schizophrenia: STEPWISE fails to make a difference

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Ben Janaway writes his debut elf blog on the STEPWISE RCT which is out today in the British Journal of Psychiatry: Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis.

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