comorbidity

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Introduction

Comorbidity, or the co-occurrence of two distinct medical conditions, is a common phrase in both physical and mental health. Whilst the term was originally conceived to describe medical phenomena, the term was adopted by psychiatry in the description of more than one clinical presentation occurring simultaneously. However, its use in psychiatry is not without controversy. 

What we know already

Large-scale prevalence data can seemingly tell us much about the high rate of comorbidity in mental health. Data from US National Comorbidity Survey, for example, suggested that, of those reporting mental health difficulties (across a 12-month prevalence), only 55% carried a single psychiatric diagnosis.

One important area of recent research concerns the rates of comorbidity of physical and mental health difficulties, particularly in the area of chronic health conditions. Mental Elf blogs have reported that people with schizophrenia are significantly more likely to die from heart disease and cancer; while the National Schizophrenia Audit calls for improved monitoring of physical health in people with schizophrenia. We know that depression and anxiety are more common when a person has a chronic health problem, and this comorbidity leads to poorer clinical and quality of life outcomes. This has led to an increase in interventions targeting the psychological consequences of chronic ill health.

Areas of uncertainty

The controversy in psychiatric comorbidity is the issues of mutual exclusivity. We are not able to conclude as to whether ‘comorbid’ psychiatric diagnoses are separate clinical entities, or multiple features of the same underlying cause. This has led to much criticism of the term ‘psychiatric comorbidity’.

Furthermore, certain diagnostic labels, such as personality disorders, attract particular scrutiny, due to their high levels of comorbidity with other mental health diagnoses. Similarly, people often meet the criteria for more than one personality disorder. This again creates uncertainty as to the precise nature of the condition, or conditions, being diagnosed.

What’s in the pipeline?

The recent publication of the Diagnostic and Statistic Manual (DSM)-5 seemingly retains the notion that multiple distinct clinical diagnoses exist, thus maintaining the argument for psychiatric comorbidity. Alternative conceptualisations have been suggested, along dimensional models, such as ‘anxious-misery’, ‘externalising’ and ‘fear-based’ dimensions. However, these were not adopted in the DSM-5.

As our understanding of mental health conditions continues to improve, so too hopefully will our understanding of comorbidity, and its relevance to psychological and psychiatric phenomena.

References

First, M. B. (2005). Mutually exclusive versus co-occurring diagnostic categories: the challenge of diagnostic comorbidity. Psychopathology, 38, 206-210. [Abstract]

Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry, 62, 617-627. [Abstract]

Naylor, C., Parsonage, M., McDaid, D., Knapp, M., Fossey, M. and Galea, A. (2012) Long-term conditions and mental health: the cost of co-morbidities. The King’s Fund, London, UK. [Full text]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our comorbidity Blogs

The healthcare cost of multimorbidity in people with mental health diagnoses in Denmark

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Kitty Saunders and Silke Vereeken explore the individual and population level healthcare costs of multimorbidities in people with at least one mental health diagnosis in Denmark.

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Is persistent anxiety and depression in childhood a one-way road to adverse outcomes in adulthood?

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In her latest blog, Laura Hankey summarises a longitudinal study using ALSPAC data that explored associations between anxiety, depression, and comorbid anxiety/depression in childhood and adverse outcomes in young adulthood.

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Genetic risk for schizophrenia is associated with changes in heart structure and function

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Nadine Parker and Ole Andreassen summarise a recent UK population-based cohort study, which looks at the impact of polygenic risk for schizophrenia on cardiac structure and function in over 32,000 people.

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South Asia’s silent struggle: people with severe mental illness suffer high burden of physical illness

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An international group of experts from the University of York CADA Implementation Science Summer School summarise a recent study on the prevalence of physical health conditions and health risk behaviours in people with severe mental illness in South Asia (Bangladesh, India and Pakistan).

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Parental mental illness a key risk factor for offspring mental illness: new evidence from Australia

The prevalence of developmental vulnerabilities in children increased with the number of parental comorbidities, with overall stronger associations for mothers compared to fathers.

Francesca Zecchinato summarises a new study which suggests that children of parents with experience of mental illness comorbidities represent a vulnerable population and should be prioritised in prevention and intervention efforts.

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Addressing premature mortality in mental illness: the “Gone Too Soon” framework

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Alvin Richards-Belle and Humma Andleeb review the Gone Too Soon framework, published yesterday in The Lancet Psychiatry, which suggests priorities for action to prevent premature mortality associated with mental illness and mental distress.

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People with severe mental health difficulties are more likely to have poor dental health and dental disorders

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Masuma Pervin Mishu summarises an umbrella review on the prevalence of dental disorders among people with severe mental illness.

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Does a diagnosis of severe physical illness elevate suicide risk?

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Dona Matthews reviews a retrospective cohort study of 47 million people exploring the risk of suicide after diagnosis of severe physical illness, such as low-survival cancers, chronic ischaemic heart disease, chronic obstructive pulmonary disease, and degenerative neurological conditions such as Huntington’s disease.

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Oral health interventions for people with severe mental illness: what enables and prevents people from accessing them?

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Vishal Aggarwal considers the findings of a recent qualitative study, which looks at the contextual factors, barriers, and facilitators to accessing oral health interventions for people with severe mental illness.

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Severe mental illness and comorbid chronic physical illness: the clock’s ticking

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In her debut blog, Jodie Ferris summarises a recent cohort study on the temporal relationship between severe mental illness diagnosis and chronic physical comorbidity in the UK, which contains important findings for care and future research.

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