comorbidity

shutterstock_135966185

Introduction

Comorbidity, or the co-occurrence of two distinct medical conditions, is a common phrase in both physical and mental health. Whilst the term was originally conceived to describe medical phenomena, the term was adopted by psychiatry in the description of more than one clinical presentation occurring simultaneously. However, its use in psychiatry is not without controversy. 

What we know already

Large-scale prevalence data can seemingly tell us much about the high rate of comorbidity in mental health. Data from US National Comorbidity Survey, for example, suggested that, of those reporting mental health difficulties (across a 12-month prevalence), only 55% carried a single psychiatric diagnosis.

One important area of recent research concerns the rates of comorbidity of physical and mental health difficulties, particularly in the area of chronic health conditions. Mental Elf blogs have reported that people with schizophrenia are significantly more likely to die from heart disease and cancer; while the National Schizophrenia Audit calls for improved monitoring of physical health in people with schizophrenia. We know that depression and anxiety are more common when a person has a chronic health problem, and this comorbidity leads to poorer clinical and quality of life outcomes. This has led to an increase in interventions targeting the psychological consequences of chronic ill health.

Areas of uncertainty

The controversy in psychiatric comorbidity is the issues of mutual exclusivity. We are not able to conclude as to whether ‘comorbid’ psychiatric diagnoses are separate clinical entities, or multiple features of the same underlying cause. This has led to much criticism of the term ‘psychiatric comorbidity’.

Furthermore, certain diagnostic labels, such as personality disorders, attract particular scrutiny, due to their high levels of comorbidity with other mental health diagnoses. Similarly, people often meet the criteria for more than one personality disorder. This again creates uncertainty as to the precise nature of the condition, or conditions, being diagnosed.

What’s in the pipeline?

The recent publication of the Diagnostic and Statistic Manual (DSM)-5 seemingly retains the notion that multiple distinct clinical diagnoses exist, thus maintaining the argument for psychiatric comorbidity. Alternative conceptualisations have been suggested, along dimensional models, such as ‘anxious-misery’, ‘externalising’ and ‘fear-based’ dimensions. However, these were not adopted in the DSM-5.

As our understanding of mental health conditions continues to improve, so too hopefully will our understanding of comorbidity, and its relevance to psychological and psychiatric phenomena.

References

First, M. B. (2005). Mutually exclusive versus co-occurring diagnostic categories: the challenge of diagnostic comorbidity. Psychopathology, 38, 206-210. [Abstract]

Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry, 62, 617-627. [Abstract]

Naylor, C., Parsonage, M., McDaid, D., Knapp, M., Fossey, M. and Galea, A. (2012) Long-term conditions and mental health: the cost of co-morbidities. The King’s Fund, London, UK. [Full text]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our comorbidity Blogs

People with mental illness are prescribed fewer drugs for physical disorders than the rest of the population

shutterstock_32769961

A year ago this week I blogged about a study in the British Journal of Psychiatry that showed the dramatically reduced life expectancy of people with severe mental illness, who on average live 15-20 years less than the rest of the population. Twelve months on and a new study published in the same journal paints an equally [read the full story…]

New NHS Confederation briefing on the future of liaison psychiatry

shutterstock_45616342

The NHS Confederation have published a new report on liaison psychiatry services that has been written by the Centre for Mental Health. Liaison psychiatry is concerned with the interface between medicine and psychiatry and typically involves patients with medical conditions that also result in psychiatric or behavioural symptoms, such as delirium. The study set out [read the full story…]

Repeat offending significantly higher in people with personality disorders, according to new systematic review

shutterstock_103071563

The excellent Time to Change initiative is quick to point out that people with mental health problems are more likely to be the victims of violence than the perpetrators. However, it remains the case that certain mental health conditions are more frequently associated with antisocial behaviour and violence than others. Personality disorders (PD) are one [read the full story…]

Peer support for people with long term conditions: guidance from the Mental Health Foundation

shutterstock_106922246

This brief new guidance will be of interest if you are involved in delivering or planning peer support for people with long term conditions. It’s the result of a research project carried out in Scotland during 2010-11, which reported that: Peer support activity for people with long term conditions across Scotland had a positive impact [read the full story…]

Self-harm is associated with poor physical health, according to new Lancet cohort study

shutterstock_53805847

Published yesterday in the Lancet, the Multicentre Study of Self-harm in England is a large (30,950 patients) cohort study of people presenting to hospital emergency departments in Oxford, Manchester and Derby, with self-poisoning or self-injury during 2000-2007. We know that people who self-harm have an increased risk of dying early, but this study tries to [read the full story…]

More research needed to help patients with multimorbidities

shutterstock_83001337

Comorbidities are common in mental health and the relationship between physical and mental health conditions appears to be bidirectional. Having a chronic physical condition like diabetes can increase your risk of depression (by as much as 3 times). Having an enduring mental health problem such as psychosis can take 15-20 years off your life. In [read the full story…]

Modular psychotherapy may be the answer for young people with comorbid depression, anxiety and conduct problems

shutterstock_46723507

Young people with mental health problems often suffer from comorbidity, i.e. a complex mix of different conditions like depression, anxiety and conduct problems. Clinical research very often investigates specific treatments (e.g. CBT) for single disorders (e.g. depression) and guidelines and manuals are then developed for clinicians to help them treat these individual conditions. The problem [read the full story…]

The dose-response association between psychological distress and mortality, new BMJ meta-analysis shows the link

shutterstock_108547067

There is an increasing body of evidence showing that depression and anxiety are linked with other health conditions like cancer and cardiovascular disease. I’ve blogged about the link between depression and stroke, and there are a number of other studies that show an association between psychological distress (the symptoms of depression and anxiety) and mortality, [read the full story…]

Depression in adults with a chronic physical health problem: new update from NHS Evidence

nhs evidence eye

NICE published a clinical guideline on the treatment and management of depression in adults with chronic physical health problems in 2009. This new evidence update refreshes that guidance by searching for new systematic reviews and randomised controlled trials on the subject and summarising them in a short (16 page) document. The authors searched a range [read the full story…]

Lifestyle education can help people with diabetes and schizophrenia lose weight, according to new systematic review

shutterstock_84001231

For many different reasons, people with schizophrenia and schizoaffective disorders have a greater risk of type 2 diabetes.  The prevalence of type 2 diabetes in people with schizophrenia is twice that of the general population. This review looked for evidence of the efficacy of interventions to help people with schizophrenia manage their diabetes. Clinical question [read the full story…]