comorbidity

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Introduction

Comorbidity, or the co-occurrence of two distinct medical conditions, is a common phrase in both physical and mental health. Whilst the term was originally conceived to describe medical phenomena, the term was adopted by psychiatry in the description of more than one clinical presentation occurring simultaneously. However, its use in psychiatry is not without controversy. 

What we know already

Large-scale prevalence data can seemingly tell us much about the high rate of comorbidity in mental health. Data from US National Comorbidity Survey, for example, suggested that, of those reporting mental health difficulties (across a 12-month prevalence), only 55% carried a single psychiatric diagnosis.

One important area of recent research concerns the rates of comorbidity of physical and mental health difficulties, particularly in the area of chronic health conditions. Mental Elf blogs have reported that people with schizophrenia are significantly more likely to die from heart disease and cancer; while the National Schizophrenia Audit calls for improved monitoring of physical health in people with schizophrenia. We know that depression and anxiety are more common when a person has a chronic health problem, and this comorbidity leads to poorer clinical and quality of life outcomes. This has led to an increase in interventions targeting the psychological consequences of chronic ill health.

Areas of uncertainty

The controversy in psychiatric comorbidity is the issues of mutual exclusivity. We are not able to conclude as to whether ‘comorbid’ psychiatric diagnoses are separate clinical entities, or multiple features of the same underlying cause. This has led to much criticism of the term ‘psychiatric comorbidity’.

Furthermore, certain diagnostic labels, such as personality disorders, attract particular scrutiny, due to their high levels of comorbidity with other mental health diagnoses. Similarly, people often meet the criteria for more than one personality disorder. This again creates uncertainty as to the precise nature of the condition, or conditions, being diagnosed.

What’s in the pipeline?

The recent publication of the Diagnostic and Statistic Manual (DSM)-5 seemingly retains the notion that multiple distinct clinical diagnoses exist, thus maintaining the argument for psychiatric comorbidity. Alternative conceptualisations have been suggested, along dimensional models, such as ‘anxious-misery’, ‘externalising’ and ‘fear-based’ dimensions. However, these were not adopted in the DSM-5.

As our understanding of mental health conditions continues to improve, so too hopefully will our understanding of comorbidity, and its relevance to psychological and psychiatric phenomena.

References

First, M. B. (2005). Mutually exclusive versus co-occurring diagnostic categories: the challenge of diagnostic comorbidity. Psychopathology, 38, 206-210. [Abstract]

Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry, 62, 617-627. [Abstract]

Naylor, C., Parsonage, M., McDaid, D., Knapp, M., Fossey, M. and Galea, A. (2012) Long-term conditions and mental health: the cost of co-morbidities. The King’s Fund, London, UK. [Full text]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our comorbidity Blogs

Is treatment for depression cost-effective in people with diabetes?

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There is evidence to suggest that people with diabetes are twice as likely to suffer from depression. It’s therefore important that the cost-effectiveness of treatments for comorbid depression be indentified. The elves have already reported on a review of the effectiveness of collaborative care for people with diabetes and depression, suggesting that the intervention might be effective. While [read the full story…]

Extended therapy with varenicline reduces rates of smoking relapse in people with serious mental health issues

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People with serious mental health issues such as schizophrenia have higher rates of cigarette smoking than the general population, with estimates suggesting more than 50% are current smokers. When people in this population do manage to quit during treatment we then see particularly high rates of relapse after treatment ends. A new randomised control trial (Evins [read the full story…]

ADHD and the importance of healthy sleep

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Good sleep is a crucial part of our physical and mental well-being. We typically spend about a third of our lives asleep but when we miss out on sleep, we can feel fatigued and struggle to concentrate. Sleep problems are generally quite common and have been reported as one of the most common health conditions [read the full story…]

Better together: how collaborative working can improve outcomes for patients with depression and diabetes

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The link between depression and diabetes mellitus (DM) is well established. Around 20% of patients with DM meet diagnostic criteria for depression. The National Institute for Health and Care Excellence (NICE) issued guidance impressing the importance of diagnosing and treating depression in long-term conditions such as DM (NICE, 2009). However, depression in the presence of [read the full story…]

Financial incentives don’t increase depression screening for patients with chronic illness

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The lines between physical health and mental health are blurred in lots of ways, and one example is the fact that people with chronic physical conditions are also more likely to suffer from depression. As well as adding to their burden of illness, there’s also some evidence that those patients with comorbid depression have worse [read the full story…]

#MindfulnessMonday – Mindfulness-based stress reduction works for patients with breast cancer

Patients with breast cancer commonly have lots on their mind (psychological distress)

Within the woodland October is a month of themes. Many of you will be familiar with #Stoptober, which always helps any elves who sneak round the the back of the woodshed, to give up smoking. You may be less aware of our #MindfulnessMonday activities that will be sprinkled across the month; showcasing the potential benefits that [read the full story…]

Psychiatric comorbidity increases the risk of premature mortality in epilepsy

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There is a back to school feeling in the air in the Woodland this week, and so this comes to you with the help of my shiny new yellow pencil case. Epilepsy affects around 70 million people around the world and premature mortality is substantial with almost half of epilepsy-related deaths occuring in those younger [read the full story…]

All scales are not equal; which is the best for detecting depression after stroke?

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Roughly 33% of stroke sufferers also develop depression at some point. This may be an under-estimate of the problem, as depression is difficult to detect in people with poor physical health. If missed, depression can led to reduced quality of life, increased disability and a worsening of physical symptoms. There are a whole host of [read the full story…]

Do interventions proven to improve cardiovascular disease outcomes work for individuals with severe mental illness?

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Individuals with severe mental illness (SMI) have shortened life expectancies compared to the general population. This is partly down to higher rates of chronic physical illness. Cardiovascular disease (CVD) is the leading cause of death among patients using mental health services. It is assumed that interventions used to reduce CVD are similarly effective in patients with [read the full story…]

Treatment of depression after a heart attack does not improve the long-term risk of adverse cardiac events but may increase survival

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Although there have been huge advances in the treatment of heart disease, it is still the UK’s biggest killer (more information on heart disease can be found at the British Heart Foundation’s website). Depression after a heart attack is common (roughly 20% prevalence) and can worsen heart disease and increase the risk of death.  A [read the full story…]