schizophrenia

Schizophrenia is a long-term mental health condition that causes a range of different psychological symptoms. These include: hallucinations (hearing or seeing things that do not exist), delusions (unusual beliefs that are not based on reality and often contradict the evidence), muddled thoughts based on the hallucinations or delusions, and changes in behaviour. Doctors describe schizophrenia as a psychotic illness. This means that sometimes a person may not be able to distinguish their own thoughts and ideas from reality.

Our schizophrenia Blogs

No sexual health history please, we’re British!

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Kirsten Lawson presents the results of a systematic review of observational cross-sectional studies, which looks at the worldwide prevalence of HIV, hepatitis B and hepatitis C in people with severe mental illness.

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Lithium for schizophrenia: Cochrane find lack of evidence to support its use

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Raphael Underwood presents a new Cochrane review of lithium for schizophrenia, which assesses the use of lithium as a monotherapy and also in combination with antipsychotics.

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Microglial activity in psychosis and schizophrenia

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Samei Huda summarises a small PET brain imaging study, which looks at two cohorts (Ultra High Risk of Psychosis v Controls and Schizophrenia v Controls) to compare relative levels of microglial activity.

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Biological pathways, antipsychotics and schizophrenia

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Murtada Alsaif summarises a small cohort study that uses shotgun mass spectrometry proteomic profiling to unravel the molecular pathways involved with antipsychotic response in people with schizophrenia.

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Does QOF reduce hospitalisation for people with severe mental illness?

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Andres Fonseca appraises a regression analysis looking at the quality and outcomes framework (QOF) and the impact it has on psychiatric admissions in people with severe mental illness.

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Rise of the machine learning algorithm: the future of diagnosing schizophrenia?

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Samei Huda reviews a meta-analysis of multivariate pattern recognition studies, which aims to detect neuroimaging biomarkers for schizophrenia.

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CBT for insomnia in people with active psychotic symptoms

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Sarah McDonald appraises the Better Sleep Trial (BEST), a pilot RCT which shows that CBT may be a promising treatment for insomnia in people with active psychotic symptoms.

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Integrated treatment for first episode psychosis: media hype versus reality

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Alex Langford reflects on the media hype surrounding a new RCT of the NAVIGATE intervention; a comprehensive, multidisciplinary, team-based treatment approach for first episode psychosis.

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Can early improvement be used to predict later response to antipsychotics in schizophrenia?

The increased risk of mood and anxiety problems found in people taking varenicline with pre-existing mental health conditions, needs to be investigated further.

Tracey Roberts summarises a recent diagnostic test review, which suggests that early improvement can act as a predictor of later response to antipsychotics in schizophrenia.

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Employment opportunities for all? Social enterprises and mental health

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Martin Webber considers a Canadian study about social enterprises and employment opportunities for people with mental health problems such as psychosis.

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