schizophrenia

Schizophrenia is a long-term mental health condition that causes a range of different psychological symptoms. These include: hallucinations (hearing or seeing things that do not exist), delusions (unusual beliefs that are not based on reality and often contradict the evidence), muddled thoughts based on the hallucinations or delusions, and changes in behaviour. Doctors describe schizophrenia as a psychotic illness. This means that sometimes a person may not be able to distinguish their own thoughts and ideas from reality.

Our schizophrenia Blogs

Omega-3 supplements for the prevention of psychosis: another trial shows no benefit, so is it time to move on?

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David Mongan reports on a recent trial of omega-3 supplementation for the prevention of psychosis in people at ultra-high risk, which finds no evidence of a positive effect. He reflects on these findings and considers what’s next for the field.

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The role of the gut microbiome in treatment-resistant schizophrenia

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Nuala Murray explores a recent Australian case-control study that looks at the associations between changes in gut microbiota and schizophrenia diagnosis, treatment resistance, and clozapine response.

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The many faces of mental disorders

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Yuri Milaneschi discusses new research on the structure and presentation of mental health disorders, which suggests that although there are many different faces of major mental disorders, some of these faces are far more common than others.

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KarXT: an innovative and promising treatment for schizophrenia

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Nicola Rizzo Pesci and Andrea Cipriani summarise findings from the EMERGENT-2 trial spotlighting a promising new drug treatment for schizophrenia.

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Just how good are antipsychotics at preventing relapse? Bridging the efficacy-effectiveness gap

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Samei Huda summarises a new network meta-analysis in the Lancet Psychiatry on the efficacy and effectiveness of antipsychotics for schizophrenia in research settings, such as randomised controlled trials, versus real-world and clinical settings.

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Brain-body health please: new research supports integrated physical and mental health care

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Athina Aruldass finds that management of serious neuropsychiatric disorders should acknowledge the importance of poor physical health and target restoration of both brain and body function.

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Early intervention for psychosis: better outcomes in the short term?

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Emanuele Osimo blogs about the 20-year follow up of the OPUS trial, which tested early intervention services for people with first-episode schizophrenia spectrum disorder.

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‘Hearing Voices’ and self-help groups: hope and support for people who hear voices

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Lorna Collins reflects on a systematic review exploring the benefits of Hearing Voices and other self-help groups for people with auditory hallucinations.

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Predicting treatment-resistant psychosis using routine clinical measures

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Lorna Staines summarises a recent study on predicting treatment-resistant psychosis, which suggests that future risk prediction efforts should seek to consider routinely collected data.

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Genetic risk for schizophrenia is associated with changes in heart structure and function

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Nadine Parker and Ole Andreassen summarise a recent UK population-based cohort study, which looks at the impact of polygenic risk for schizophrenia on cardiac structure and function in over 32,000 people.

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