bipolar disorder

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Introduction

Bipolar, otherwise known as manic depression, now exists largely within common consciousness and understanding, thanks to high profile stigma-busting publicity.

Characterised by episodic shifts in a person’s mood (between manic and depressed states), as well as their energy and activity levels, which can significantly impact their daily functioning, bipolar is estimated to affect 1% of the population across the lifetime. However, this figure rises to over 4% if you include those who experience more than one episode of sub-threshold manic (or ‘hypomanic’) symptoms.

What we know already

Anxiety is unsurprisingly common in people living with bipolar. Similarly, substance abuse is frequently reported.

Whilst there is no cure, there are several well-established treatment options. Bipolar is usually treated using mood-stabiliser, atypical anti-psychotic and/or antidepressant medications, alongside psychological, and diet and lifestyle interventions. We know, for example, that bipolar can be well managed using regular monitoring of mood, keeping stress levels to a minimum, and ensuring good sleep.

Areas of uncertainty 

Like many mental health difficulties, the precise causes of bipolar are unknown, though they are likely multi-faceted. Research shows that you are more likely to develop bipolar if it exists in your family. Although most children with such circumstances will not go on to develop bipolar, there appears to be a strong genetic component. Environmental factors such as stressful life events are also thought to play an important role.

Recent research suggests that, whilst it appears beneficial to treat bipolar with psychological interventions, the heterogeneity of the evidence makes it difficult to decide which treatments (such as CBT, Mindfulness etc) work best.

What’s in the pipeline?

Large-scale studies, such as the U.S-based Bipolar Disorder Phenome Database, are seeking to better understand the complex genetic picture.

Advances in brain imaging will no doubt provide rich information regarding the neurochemical and neurostructural profile of bipolar. Similarly, technological advances are enabling more sophisticated ways of promoting self-management in conditions such as bipolar.

References

Merikangas, K.R., Akiskal, H.S., Angst, J., et al. (2007) Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Archives of General Psychiatry, 64, 543-552. [Abstract]

Stratford, H.J., Cooper, M.J., Di Simplicio, M., Blackwell, S.E. and Holmes, E.A. (2015) Psychological therapy for anxiety in bipolar spectrum disorders: a systematic review. Clinical Psychology Review, 35, 19-34. [Abstract]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our bipolar disorder Blogs

Review identifies a lack of research about the long-term employment outcomes for people with bipolar disorder

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Back in October I blogged about the factors (cognitive deficits, depression and education level) that predict worklessness in people with bipolar disorder. A new systematic review by Steven Marwaha and colleagues has recently been published in the Acta Psychiatric Scandinavica journal, which adds to our understanding of this field. The review looks at the long-term [read the full story…]

People with mental illness are prescribed fewer drugs for physical disorders than the rest of the population

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A year ago this week I blogged about a study in the British Journal of Psychiatry that showed the dramatically reduced life expectancy of people with severe mental illness, who on average live 15-20 years less than the rest of the population. Twelve months on and a new study published in the same journal paints an equally [read the full story…]

Cognitive deficits, depression and education level all predict worklessness in bipolar disorder, says systematic review

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People with bipolar disorder have high levels of post 16 years education, but it’s estimated that only half of those living in Europe with the condition are in paid employment. This is a real concern because the illness typically affects young and middle-aged people who would normally be active in the workforce. Of course, living [read the full story…]

Making workplace adjustments for people with mental health problems: new guidance from the Department of Health

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There’s a growing body of evidence that shows how relatively minor adjustments in the workplace can have a huge impact on supporting people with mental health problems and help them stay in work. The Department of Health has published guidance that will help employers think through the changes that they can make in the workplace [read the full story…]

Short-term use of second-generation antipsychotics can cause side effects in children and adolescents

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Over the last few years, we have seen more and more children and young people being prescribed antipsychotic drugs. The theory behind this increase is that the newer antipsychotic drugs have fewer side effects than the older typical antipsychotics. However, some small and relatively short duration studies have shown that the newer drugs may also [read the full story…]

Haloperidol reduces mania a little faster than second-generation antipsychotics, according to systematic review

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There are a range of treatment options for people with bipolar disorder who are experiencing a manic episode. An important part of this treatment is to reduce the symptoms of mania and provide the individual with some level of normality. I blogged this time last year about a meta-analysis in the Lancet that showed that [read the full story…]

Over 40% of US teenagers experience a mental health disorder in any 12 month period

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This new cross sectional study from researchers at Harvard Medical School looks at the prevalence of DSM-IV disorders in over 10,000 teenagers living in the community. The study looked at a representative sample of young people. Homeless adolescents, school drop-outs and non-English speakers were excluded from the research, even though those who speak a different [read the full story…]

Premature babies have greater risk of serious mental illness

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Preterm babies are three times more likely to be admitted to hospital for a mental health problem as an adult than normal term babies, according to a study published in the Archives of General Psychiatry by researchers in the UK and Sweden. About 1 in every 13 children born in the UK are classified as [read the full story…]

New systematic review shows how the incidence of schizophrenia and other psychoses has changed since 1950

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This is one in a series of 5 systematic reviews commissioned by the Department of Health, which seek to establish a comprehensive understanding of the distribution and pattern of psychotic disorders in England, between 1950 and 2009. All mental health professionals, commissioners and health planners will find this research relevant to their work. It’s well [read the full story…]

The side effects of lithium: new systematic review provides toxicity profile

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Lithium is a medicine that has been used for over 50 years to treat depression and bipolar disorder. It comes in two forms that are used clinically: lithium carbonate and lithium citrate. A certain level of the drug is needed in the blood stream for it to be effective, but if the level rises too [read the full story…]