bipolar disorder

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Introduction

Bipolar, otherwise known as manic depression, now exists largely within common consciousness and understanding, thanks to high profile stigma-busting publicity.

Characterised by episodic shifts in a person’s mood (between manic and depressed states), as well as their energy and activity levels, which can significantly impact their daily functioning, bipolar is estimated to affect 1% of the population across the lifetime. However, this figure rises to over 4% if you include those who experience more than one episode of sub-threshold manic (or ‘hypomanic’) symptoms.

What we know already

Anxiety is unsurprisingly common in people living with bipolar. Similarly, substance abuse is frequently reported.

Whilst there is no cure, there are several well-established treatment options. Bipolar is usually treated using mood-stabiliser, atypical anti-psychotic and/or antidepressant medications, alongside psychological, and diet and lifestyle interventions. We know, for example, that bipolar can be well managed using regular monitoring of mood, keeping stress levels to a minimum, and ensuring good sleep.

Areas of uncertainty 

Like many mental health difficulties, the precise causes of bipolar are unknown, though they are likely multi-faceted. Research shows that you are more likely to develop bipolar if it exists in your family. Although most children with such circumstances will not go on to develop bipolar, there appears to be a strong genetic component. Environmental factors such as stressful life events are also thought to play an important role.

Recent research suggests that, whilst it appears beneficial to treat bipolar with psychological interventions, the heterogeneity of the evidence makes it difficult to decide which treatments (such as CBT, Mindfulness etc) work best.

What’s in the pipeline?

Large-scale studies, such as the U.S-based Bipolar Disorder Phenome Database, are seeking to better understand the complex genetic picture.

Advances in brain imaging will no doubt provide rich information regarding the neurochemical and neurostructural profile of bipolar. Similarly, technological advances are enabling more sophisticated ways of promoting self-management in conditions such as bipolar.

References

Merikangas, K.R., Akiskal, H.S., Angst, J., et al. (2007) Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Archives of General Psychiatry, 64, 543-552. [Abstract]

Stratford, H.J., Cooper, M.J., Di Simplicio, M., Blackwell, S.E. and Holmes, E.A. (2015) Psychological therapy for anxiety in bipolar spectrum disorders: a systematic review. Clinical Psychology Review, 35, 19-34. [Abstract]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our bipolar disorder Blogs

Searching for the cost of bipolar disorder

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Bipolar disorder is associated with high economic costs…or is it? Chris Sampson reports on a new systematic review, which highlights limitations in our understanding.

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Psychotherapies for anxiety in bipolar disorder

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Elena Marcus finds inconclusive results in this recent systematic review of psychological therapy for anxiety in bipolar spectrum disorders, which includes trials of CBT, mindfulness based cognitive therapy and stress management therapy.

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Online social networking and psychosis

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Nikki Newhouse reports on a recent systematic review of online social networking and psychosis. Her blog explores the potential benefits and harms of online social networking for people with psychosis, and reflects on some of the challenges facing researchers working in the field.

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Medication for the maintenance treatment of bipolar disorder

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Elena Marcus summarises a recent network meta-analysis published in The Lancet of the comparative efficacy and tolerability of medication for the maintenance treatment of bipolar disorder.

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Folic acid for depression: RCT finds no effect on reducing incidence of depression or bipolar

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Elly O’Brien summarises a recent RCT of folic acid for depression, which explores whether mood disorders can be prevented in young people at familial risk. The trial finds no evidence that folic acid supplementation reduces the incidence of mood disorders compared to those taking placebo.

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Stigma in bipolar disorder and borderline personality disorder: time for a cultural shift.

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Andrew Shepherd summarises a critical realist analysis that looks at experiences of stigma in people with bipolar disorder or borderline personality disorder. He concludes that a profound social change in public and professional attitudes is necessary before mental health stigma can be effectively eradicated.

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Cannabis and mania: what’s the link?

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Kathryn Walsh summarises a systematic review which finds that cannabis use may exacerbate symptoms of mania in those with a diagnosis of bipolar disorder, and trigger symptoms of mania in the general population.

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Bipolar disorder, suicide and criminality

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Elena Marcus summarises a double case-cohort study, which investigates the risk of suicide and criminal behaviours in people with bipolar disorder and their siblings, compared with the general population.

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Are treatments for bipolar disorder cost-effective?

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Chris Sampson reports on a recent systematic review and critical appraisal of economic evaluations in bipolar disorder. He finds that there’s a pressing need for new studies, especially discrete event simulations.

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Bipolar disorder and leadership: evidence from a total population study

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Elena Marcus writes her debut blog on a total population study that finds some interesting associations between bipolar disorder and leadership potential, executive roles and political professions.

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