This review comparing the efficacy and safety of topical antifungal drugs for oral candidiasis in children and adults included 11 RCTs 9 of which concerned adults and 2 children. The findings support the use of fluconazole and amphotericin B for adults.
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Iris Vaid takes a look at this review of whether e-cigarettes have a negative impact on the cells in the head, neck, and mouth. 16 in-vitro studies showed that oral cells exposed to e-cigarettes showed aberrant cell morphology, reduced cell viability, and increased apoptosis and/or necrosis.
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This Cochrane review update of interventions for the prevention or treatment of medication-relatesd osteonecrosis of the jaw (MRONJ) included 13 RCTs. However the studies provided insufficient to either claim or refute a benefit of the interventions tested for prophylaxis or treatment of MRONJ.
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In her first Dental Elf blog Iris Vaid looks at a review of salivary lactate dehydrogenase (LDH) as a potential diagnostic marker for oral cancer and oral potentially malignant disorders.
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This review of the evidence on possible association between locally delivered nicotine replacement therapy(NRT) and oral side effects included 28 RCTs. Most of the RCTs were at high risk of bias mainly because of allocation concealment concerns. Reported oral side effects including oral soreness, gastric reflux or vomiting, and mouth or throat irritation.
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This review assessing a potential association between early childhood caries (ECC) and iron deficiency anaemia (IDA) included 14 studies. While the findings showed an association between ECC and IDA the certainty of the evidence was very low so the findings should be interpreted very cautiously,
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This review of the effect of additives incorporated into lidocaine solution on the success of inferior alveolar nerve block (IANB) included 12 RCTs. The findings suggest that additives did not improve the success rate of IANB but the evidence is of low to very low certainty.
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This Cochrane review update of antibiotic prophylaxis before invasive dental procedures in people at risk or at high risk of bacterial endocarditis included one case-controlled study. Consequently, there is no clear evidence about whether antibiotic prophylaxis is effective or ineffective against bacterial endocarditis in at-risk people who are about to undergo an invasive dental procedure.
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This review of comparing photodynamic therapy (PDT) and antifungals or the treatment of denture stomatitis included 5 studies involving a total of 218 patients. While the findings suggest that PDT is effective none of the the studies was at low risk of bias and the treatment protocols investigated differ.
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This review of the effect of pre-emptive ibuprofen on post-operative pain after lower third molar surgery included 5 RCTs. Only one of the included studies was at low risk of bias so there is insufficient evidence to support the routine use of pre-emptive ibuprofen to reduce post-operative pain after lower third molar removal
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