Sarah Knowles

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Sarah is a Research Fellow with the NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) Greater Manchester at the University of Manchester. She is a health researcher with a particular focus on evaluating mental health treatments and services. She works on a variety of randomised controlled trials, systematic reviews and qualitative studies. Her main research interests are implementation research, e-health and mental health technologies, co-morbidity of mental and physical health problems, moderators of treatment effects and patient and public involvement in research.

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Moderators of outcome in late-life depression: should we be prescribing antidepressants to older people?

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Meta-analyses are an incredibly useful tool for synthesising evidence. However, such analyses typically use aggregate data, meaning the average scores or outcomes for treatment groups, which can cause problems if we’re trying to dig a little deeper into the question of ‘what works’ to answer ‘what works, and for whom?’ The ‘for whom?’ question is [read the full story…]

Meta analysis of antidepressants vs talking therapies: another example of ‘All Must Have Prizes’?

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Patients presenting to their GP with a mental health problem are likely to be offered medication, in the form of antidepressants, and/or a ‘talking therapy’, such as counselling or CBT. This is because we know that both those broad categories of treatments (drugs and psychological therapies) are effective in reducing symptoms. However, it’s less clear [read the full story…]